IL6 and viral infectious disease: Viral infections may trigger host inflammation resulting in the production of cytokines that lead to vasodilation, neutrophil extravasation, and leakage of plasma into the infected tissue.5 Intracellular multiplication of SARS-CoV-2 results in increased levels of the pro-inflammatory interleukin (IL)-6, tumour necrosis factor (TNF)-α, IL-1β, IL-2, interferon (IFN)-γ, and IL-10.6 There are three main pathways of IL-6 signal transduction: cis signalling, trans signalling, and trans presentation.