CD4 and myeloid sarcoma: Given their central nature in EAE, much MS/EAE research has focused on CD4+ T cells.8 Myelin-specific CD4+ Th1 cells are sufficient to induce EAE, which is evoked on adoptive transfer of such cells into naive recipient mice.9 T-helper 17 (Th17) cells have also been demonstrated to be important for the development of EAE.10