Between the no-AT and AC ± APT groups, significant differences were seen in age (69 years vs. 79.5 years, respectively; P < 0.001), presence of gallstones (86.4% vs. 67.4%, respectively; P = 0.012), severity grade I (47.6% vs. 13.0%, respectively; P < 0.001), ASA-PS ≥ 3 (34.1% vs. 76.1%, respectively; P < 0.001), CRP (6.9 mg/dL vs. 13.1 mg/dL, respectively; P < 0.001), Cr (0.8 mg/dL vs. 0.9 mg/dL, respectively; P = 0.017), blood loss (10 mL vs. 114 mL, respectively; P = 0.017) and length of hospital stay (6 days vs. 8 days, respectively; P < 0.001). The gene discussed is CRP; the disease is gallstones.