Therefore, in this longitudinal study, which evaluated treatment response, and not treatment resistance or remission, we expected that COMT rs4680 A allele, COMT rs4818 C allele, and C-A (rs4680–rs4818) haplotype, will be more frequently represented among patients with schizophrenia with a good response to treatment. The gene discussed is COMT; the disease is schizophrenia.