A 2.4-fold overrepresentation (Z-score 5.9, P < 0.0000001) of RUNX1 binding sites overlapping with heptamers without adjacent nonamer motif and a 3.7-fold overrepresentation (Z-score 5.0, P < 0.00004) of RUNX1 heptamer motifs within a RSS were found in ETV6-RUNX1 B-ALL deletion borders as compared to RUNX1 motif overlap with single heptamers and RSS backgrounds taken from the entire genome. Here, ETV6 is linked to acute lymphoblastic leukemia.