Our analysis for RUNX1 motifs revealed that in ETV6-RUNX1 ALL the sequences at the deletion borders display a 2.4-fold overrepresentation (Z-score 5.9) in 65 heptamer hits and 3.7-fold overrepresentation (Z-score 5.0) within 15 heptamer hits within RSS modules. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.