The number of ductal cysts formed by KC ADM cells following AurkA inhibition with MLN8237 was significantly reduced from 89.98±2.2% in DMSO-treated KC ADM cells to 65.39±2.1% in MLN8237-treated cells (P<0.0001) (Fig. 6B,F; n=10 wells across three biological replicates). This evidence concerns the gene AURKA and keratoconus.