KRAS and familial pancreatic carcinoma: Indeed, AurkA is regulated by KRAS via the MAPK signalling pathway, and, consequently, AurkA is ectopically expressed in pancreatic cancer and KRAS knockdown in PDAC cell lines leads to depletion of AurkA and cilia formation (Furukawa et al., 2006; Li et al., 2003; Kobayashi et al., 2016).