IL5 and Increased total eosinophil count: Eosinophilia at tissue sites of inflammation can be mediated by a number of distinct molecules or pathways, including ILs such as IL-2, IL-3, and IL-5; growth factors, such as (G)M-CSF; chemokines such as CCL5, 11, 24, and 26; and leukotrienes, such as leukotriene B4 (48, 49).