CD28 and parasitic infectious disease: We analyzed the expression profiles of the well-defined and inflammation or parasitic infection-driven phenotypic markers, such as the systemic highly upregulated CD86 and CD69 markers (59–61), the blood highly upregulated CD28 marker (59, 60); the lung, blood, and bone marrow upregulated MHCII and RELMα markers (59, 62, 63); and the peritoneum, bone marrow and blood downregulated CCR3 marker (64, 65).