IL4R and infection: At 12 wk postinfection (Fig. 3), eosinophilia was significantly impinged in IL-4Rα−/−CCR3−/− double-knockout mice compared with WT infections, whereas as IL-4Rα−/− mice exhibited an intermediate eosinophilia that was not significantly inferior to eosinophil levels in WT mice (median eosinophil levels of 0.52 × 106, 0.087 × 106, and 0.05 × 106 for WT, IL-4Rα−/−, and IL-4Rα−/−CCR3−/− mice, respectively; Kruskal–Wallis one-way ANOVA statistic 10.3, p < 0.01; Fig. 3A, 3B).