IL4R and Increased total eosinophil count: We determined eosinophilia was profoundly impaired in IL-4Rα−/−IL-5−/− mice compared with either WT or the residual eosinophil level in IL-4Rα−/− mice (median eosinophilia 0.02 × 106 versus 0.7 × 106, WT or 0.18 × 106, IL-4Rα−/−, Kruskal–Wallis one-way ANOVA statistic: 21.5, p < 0.001 or p < 0.05, Dunn multiple comparisons tests; Fig. 4A, 4B).