MNX1 and Cowden syndrome 1: Among the seventeen CS patients and eight affected relatives (I-1 in family 5; I-1 in family 6; II-2, II-4, II-6, III-2 and III-4 in family 7; and I-2 in family 9) who had at least MRI changes, eighteen were detected to have pathogenic (or likely pathogenic) variants in MNX1 (18/25).