Mutations in the microtubule-associated protein tau (MAPT) gene cause different familial forms of frontotemporal lobar degeneration (FTLD) including Pick’s disease (PiD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and globular glial tauopathy (GGT) [23, 39, 80]. This evidence concerns the gene MAPT and Pick disease.