In addition to RA onset, Viatte et al. further examined 20 SNPs (rs6013897, rs17217119, rs10500804, rs1993116, rs10741657, rs7116978, rs127947147, rs127858787, rs12800438, rs4944076, rs4944997, rs7944926, rs4945008, rs3829251, rs2298850, rs3755967, rs2282679, rs1155563, rs17467825, rs7041) from four vitamin D metabolism genes (GC, DHCR7/NADSYN1, CYP2R1, and CYP24A1) with RA radiological outcome, as reflected by Larsen score and presence of erosion. The gene discussed is CYP2R1; the disease is rheumatoid arthritis.