Their result showed the administration of combined anti-CTLA-4 therapy (9H10), anti-PD-1 therapy (RMP114), and agonistic anti-4-1-BB therapy (3H3), induced bilateral tumor regression in 40% of mice while the STING agonist CDG added, markedly inhibited the bilateral tumors in 75% of these mice. Here, CTLA4 is linked to neoplasm.