In addition, we also noticed that Sophoridine suppresses TGF-β-induced EMT process, and the following migration and invasion depends on tumor-suppressor ESRRG, different from its effect in human colorectal cancer cells, in which Sophoridine inhibits cellular invasion via directly binding to MAPKAPK2 and inactivates its phosphorylation [15]. This evidence concerns the gene MAPKAPK2 and colorectal cancer.