MAPK8 and familial pancreatic carcinoma: The underlying anti-tumor mechanisms of Sophoridine including increase of intracellular ROS levels, activation of the phosphorylation of ERK and JNK, induction of S phase arrest in pancreatic cancer cells [14]; inhibition of growth and invasion in human colorectal cancer cells via directly binding to MAPKAPK2 and inactivates its phosphorylation [15]; inhibition of ubiquitin-proteasome pathway in human glioma cells [16].