EPCAM and prostate neoplasm: The CellSearch® system (Menarini Silicon Biosystems, Castel Maggiore, BO, Italy), a CTCs detection method based on immunological assay with the epithelial cell adhesion molecule (EpCAM), was placed on the market by Veridex Corporation (Warren, NJ) in 2004, which is currently the first and only FDA-approved CTCs assay for monitoring colorectal, breast, prostate tumors, etc. [14].