Imatinib turned out to block PDGF receptor at low dose, exerting a pharmacological effect for BCR-ABL positive CML and FIP1L1-PDGFRA mutated eosinophilic leukemia patients [51, 52], suggesting PDGF signaling as an activated effector in hematological malignancies. The gene discussed is FIP1L1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.