Meanwhile, considering the clinical implication of hypercalcemia, a differential diagnosis of sarcoidosis was established based on elevated levels of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3, 151.0 ng/L, normal range: 20.0–60.0 ng/L) and sarcoidosis markers: angiotensin-converting enzyme (ACE, 39.7 U/L, normal range: 7.0–25.0 U/L), lysozyme (37.9 mg/L, normal range: 5.0–10.2 mg/L), and soluble interleukin-2 receptor (SIL-2R, 3190 U/ml, normal range: 145–519 U/ml). The gene discussed is ACE; the disease is sarcoidosis.