Furthermore, TAMs are a source of cytokines such as TGF-β1, STI1 (stress inducible protein 1), EGF (epidermal growth factor), IL-6 (Interleukin 6) and IL-1β (Interleukin 1 Beta) that promote growth, migration and mesenchymal transformation of the tumor cells (Figure 4) [131,133]. This evidence concerns the gene TGFB1 and neoplasm.