EGFR and central nervous system cancer: A previous analysis focused on gliomas revealed three DNA-methylation clusters among IDHwt tumors: RTK I, enriched in PDGFRA amplifications, RTK II, characterized by high frequency of chromosome 7 gain and chromosome 10 loss, as well as EGFR amplifications; and mesenchymal tumors, which show a methylation profile most similar to normal brain tissue despite substantial copy number changes.