For instance, CD4+CD25hi Tregs and tumor-derived γδ Tregs cause DNA damage-associated senescence in effector T cells through nutrient competition, resulting in the activation of a senescence signaling network involving ATM, MAPKs (ERK1/2 and p38 MAPK), and STAT1/3 protein [103,104]. This evidence concerns the gene CD4 and neoplasm.