Meanwhile, when PSPC1 is overexpressed in HCC cells, PSPC1 not only loses its sequestration of tumor suppressive PTK6 in the nucleus but also facilitates PTK6 cytoplasmic translocation to be an oncogene and β-catenin nuclear translocation to interact with PSPC1 for augmenting Wnt3a autocrine signaling and tumor progression [41]. The gene discussed is PSPC1; the disease is hepatocellular carcinoma.