Since PSPC1 was shown to elevate matrix complex degradation enzymes matrix metalloproteinases (MMPs) for breaking the ECM physical barrier to facilitate metastasis [11], our detailed mechanism of PSPC1-activated dynamic ECM remodeling, cell surface integrin modulation along with stimulation of FAK/Src kinase signaling further advance our understanding PSPC1-driven tumor metastasis. This evidence concerns the gene PTK2 and neoplasm.