Recently, we reported that PSPC1 could potentiate TGF-β1 autocrine signaling to cancer cells and function as the master activator of epithelial to mesenchymal transition (EMT) and the stemness via activation of EMT and stemness core transcription factors such as Snail, Slug, Twist and Nanog, Oct4, Sox2, respectively [39,40]. The gene discussed is PSPC1; the disease is cancer.