RAB27A and early-onset autosomal dominant Alzheimer disease: For example, Rab27a was found to be upregulated in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer’s disease [20] and silencing Rab27a in primary hippocampal neuronal cultures resulted in attenuated calcium release from intracellular acidic calcium stores probably by attenuated exocytotic insertion of N-type calcium channels into the plasma membrane [21].