GFAP and amyotrophic lateral sclerosis: Administration of 100 mg/kg PCA beginning at disease onset significantly reduced astrogliosis in the ventral horn of the lumbar spinal cord in the hSOD1G93A mouse model of ALS from a mean 394% increase to a mean 258% increase in GFAP fluorescence units relative to the WT littermate control (p < 0.05, Figure 6B).