Although the functions of AGR2 in cancers have been studied intensively in recent years, so far only a few strategies have been demonstrated to regulate AGR2 expression, such as hormone dependent regulation [15], various microRNAs [16,17], shortening of 3’UTR (3’untranslated region) mRNA [18], and endoplasmic reticulum stress [19]. The gene discussed is AGR2; the disease is cancer.