Both play pro-oncogenic roles in cancer: TNFAIP3 is a ubiquitin-editing enzyme that binds and inhibits E3 ubiquitin ligase RNF168 responsible for regulating histone H2A turnover key to proper DNA repair, while CHD1L is a DNA helicase possessing chromatin remodeling functions important for early embryonic development and promotes cell proliferation and anti-apoptosis. This evidence concerns the gene CHD1L and cancer.