Both ARID1A and CDKN2A mutations are context dependent tumor suppressor genes that may be targetable in a synthetic lethal pair such as with a EGLN (prolyl hydroxylase) inhibitor (targeting HIF1α) or MTAP deletions with a PRMT5 (arginine N-methyltransferase 5) inhibitor dependent tumors respectively [42]. The gene discussed is CDKN2A; the disease is neoplasm.