From germline variants found to be in cancer predisposition genes, six (all heterozygous) were identified to be pathogenic or likely pathogenic by the more stringent ACMG guidelines: BRCA2-Q2859Kfs (gray zone lymphoma), SDHA-R75* (spindle cell breast cancer), SDHC-A3Rfs (gastrointestinal stromal tumor), RUNX1-M151L (glioblastoma), FANCC-c.456+4A>T splice site/exon skipping (anaplastic astrocytoma), and MUTYH-G396D (alveolar soft part sarcoma) (Table 2). The gene discussed is BRCA2; the disease is gastrointestinal stromal tumor.