Most of the studies using this strategy have been undertaken in animal models of RCC and in patients with non-metastatic RCC, using the chimeric human-mouse monoclonal antibody G250 (RENCAREX/GIRENTUXIMAB), which is a safe, well tolerated antibody that was found to prolong disease-free survival by up to 22 months in a subgroup of ccRCC patients with high tumour CAIX expression [164]. This evidence concerns the gene CA9 and neoplasm.