On one hand, the observed down-regulation of T-cadherin (indicated as the storage Acrp30 receptor) in tumor tissues has been reported to be associated with an up-regulation of T-cadherin in the vasculature that could partially determine a reduction in Acrp30 production by the local infiltrating adipose tissue; this decrease of local Acrp30 in turn determines AdipoR1 up-regulation (in this regard, TME affects adiponectin production and function). This evidence concerns the gene ADIPOQ and neoplasm.