CD40LG and rheumatoid arthritis: Nevertheless, it is intriguing that, different to controls, the proportion of subjects with evidence of recent exposure to Aa (anti-LtxA IgM, IgG and/or IgA positive individuals) was more frequent during pre-symptomatic (OR 2.12 95%CI 1.04, 4.30), early RA (OR 3.88 95%CI 1.81, 8.26) and established RA (OR 2.90 95%CI 1.21, 6.91) (Table 2).