A short time exposure to B-cell activation mimetic PMA favors the NOTCH2/FCER2 (CD23) axis, whereas long-term stimulation with PMA shifts the NOTCH2/FCER2 (CD23) axis to the NOTCH3/NR4A1 axis in CLL cells. This evidence concerns the gene NR4A1 and B-cell chronic lymphocytic leukemia.