RO4929097 increased apoptosis in CLL cases expressing GSI-S nuclear NOTCH2 (p = 0.003; n = 7) and, surprisingly, decreased apoptosis in CLL cases expressing GSI-R nuclear NOTCH2 (p = 0.001; n = 9) (Figure 2C), irrespective of the NOTCH1 mutational status (Figure 2D). This evidence concerns the gene NOTCH1 and B-cell chronic lymphocytic leukemia.