CD4 and neoplasm: Mice implanted with 4T1luc2-rtTERT_H9, capable to restrict tumor growth, exhibited increased percent of CD4+ and CD8+ T cells responding to stimulation with TERT1, 6, and 8 by mono- and multicytokine production, dominated by secretion of TNF-γ (up to 6% of CD4+ and 11% of CD8+ T cells) and also cytokine response to the autoepitope in TERT2 (Figure 10A,B and Supplementary Figure S9).