For example, the redistribution of essential metals in the liver of breams (Abramis brama L.)revealed that the accumulation of Cu and K increased at the stage of anemia development, while it decreased at the stage of protective function mobilization and enhanced hemopoiesis, probably as a result of the depletion of Cu storage in ceruloplasmin and metallothionein [22]. The gene discussed is CP; the disease is anemia (phenotype).