CASP3 and colorectal adenocarcinoma: Kustiawan et al. also found that cardol isolated from SBP has been used to treat human colorectal adenocarcinoma cell lines, induced changes in cell morphology, increased the expression of apoptotic proteins (caspase-3 and caspase-9) and also cleavage of pro-caspase-3, pro-caspase-9 and poly (ADP-ribose) polymerase (PARP) [92].