However, the PAI-1 +11053TG + GG genotype was related to a protective effect against CRC for patients aged < 61 years (AOR = 0.563; 95% CI: 0.333–0.950; p = 0.03), with HTN (AOR = 0.618; 95% CI: 0.382–1.001; p = 0.05), without DM (AOR = 0.633; 95% CI: 0.425–0.942; p = 0.02), with folate ≥ 3.8 ng/mL (AOR = 0.669; 95% CI: 0.448–0.999; p = 0.05), and with BMI ≥ 25 (AOR = 0.420; 95% CI: 0.192–0.920; p = 0.03). This evidence concerns the gene SERPINE1 and diabetes mellitus.