SERPINE1 and colorectal carcinoma: In this study, we investigated the effect of five PAI-1 gene polymorphisms (-675 4G > 5G [rs1799889], -844G > A [rs2227631], +43G > A [rs6092], +9785G > A [rs2227694], and +11053T > G [rs7242]) on the risk of CRC in a Korean population-based case-control study.