SERPINE1 and hypertensive disorder: The PAI-1 -675 4G5G + 5G5G genotype with HTN was three times more likely to develop CRC than the 4G4G genotype without HTN and was five times more likely to develop CRC in patients with a folate level ≤ 3.8 nmol/L (Figure 1 and Supplementary Table S5).