SERPINE1 and colorectal carcinoma: Therefore, we designed a genetic epidemiological study of five PAI-1 polymorphisms (PAI-1 −675 4G > 5G [rs1799889], −844G > A [rs2227631], +43G > A [rs6092], +9785G > A [rs2227694], and +11053T > G [rs7242]) to investigate the association between PAI-1 and CRC.