In the above-mentioned publication, Gao et al. have also shown that leptin stimulates cell proliferation and induces activation of signal transducers and transcription 3 activators (STAT3), extracellular signal-controlled kinase (ERK1/2), AKT and cyclooxygenase (COX) -2 in endometrial cancer cells [23]. This evidence concerns the gene AKT1 and endometrial cancer.