In our other project, we demonstrated Oligo-Fucoidan binds to ASGPR1/2 receptor in normal hepatocyte or hepatoma cells through both in-vitro and in-vivo competition assay, and activate pSTAT3 and bind to the promoter of HNF4a-P1 isoform and increase the expression of Hnf4a (unpublished result). Here, HNF4A is linked to hepatocellular carcinoma.