We compared two batches of transgenic fish radiation (1st batch-HBx, src fish diet-induced obesity (DIO) with 40 Gy and 2nd batch- HBx, src, p53-transgenic fish DIO with 10 Gy) with or without Oligo-Fucoidan pretreatment. Here, TP53 is linked to obesity due to melanocortin 4 receptor deficiency.