A number of radio-protectants have been reported, amifostine ameliorated radiation-induced mutagenesis but is limited by its inherent systemic toxicity [70], nicaraven had very limited effects on tumor growth [71], and although tangeretin reduces irradiation-induced lung metastasis, it provokes food-drug interactions via causing CYP3A4 induction [72]. This evidence concerns the gene CYP3A4 and neoplasm.