We also identified 234 genes that were upregulated by 40 Gy irradiation in HBx,src transgenic fish with DIO (DIO + R/DIO) and upregulated by Oligo-Fucoidan pretreatment before radiation in both batches (DIO + OF + R/R) at least two-fold with a p-value less than 0.05, and those genes involved Oligo-Fucoidan also decreased the expression of genes involved in nuclear outer membrane-endoplasmic reticulum membrane network and non-homologous end-joining (NHEJ) in HCC transgenic fish (Figure 7D–F). This evidence concerns the gene SRC and hepatocellular carcinoma.