In order to investigate the anti-apoptosis role of Sirt1 in Non-GCB DLBCL cells, we first used CCK-8 assay to detect cell viability after Adriamycin treatment in each group of LY-3 and LY-10 cells at 24, 48 and 72 hours. This evidence concerns the gene SIRT1 and diffuse large B-cell lymphoma.