DDB2 and melanoma: We previously reported very low levels of XPC, DNA-damage binding protein 1, and DNA-damage binding protein 2 in melanoma cell lines that are not inducible by carboplatin or its analogue, cisplatin.[2,3] Subsequent analysis of advanced primary and metastatic melanomas from the Hunter region, NSW, Australia and the Cancer Genome Atlas (TCGA) data from 378 melanomas identified very low levels of XPC expression.[4] Analysis of XPC methylation using Illumina 450K methylation array data from the 378 TCGA melanomas.