Pharmacotherapeutic interventions commonly used in the treatment of AM, including oral contraceptives (OCs), gonadotropin-releasing hormone agonist (GnRH-a), progestins, danazol, selective estrogen receptor modulators, selective progesterone receptor modulators, and aromatase inhibitors.[9] Guidelines recommend OCs, Levonorgestrel-releasing intrauterine system (LNG-IUS) and GnRH-a.[10] OCs are first-line treatments that can control dysmenorrhea and reduce recurrence. This evidence concerns the gene GNRH1 and Dysmenorrhea.