ACVR1B and gout: Noticeably, INHBB/INHBC/INHBE and ACVR1B/ACVRL1 inhibin-activin encoding genes have been associated with serum urate loci.[27] Another intriguing study elucidated the structural and functional relationship between LRP1 and LRP2, which was associated with serum UC in a GWAS among East Asians.[28] All these findings suggest that LRP1 may affect the progression of gout by regulating the expression of gout and UC-related genes.