As shown in Figure 4A and 4C, the results of western blot and qPCR demonstrated that the protein and mRNA levels of MMP-3 and MMP-9 were higher in TNF-α–treated RA FLS transfected with BMP3-RNAi compared to the cells transfected with NC-RNAi. The gene discussed is BMP3; the disease is rheumatoid arthritis.