We conducted three studies in varied Ugandan settings to obtain a comparative assessment of allergy-related disease prevalence and risk factors in rural36 and urban37 settings, and among asthmatic children and controls.38 These studies provide an unprecedented opportunity to assess anti-CCD IgE profiles, their relevance to epidemiological trends of allergic sensitization and asthma, and their association with the rural-urban environment and Sm exposure in tropical LICs. The gene discussed is IGHE; the disease is asthma.