Biological processes analysis showed that the cAMP-mediated signaling (GO: 0019933), the cAMP biosynthetic process (GO: 0006171), and the adenylate cyclase – activating/inhibiting G-protein coupled receptor signaling pathway (GO: 0007193 and 0007189) were significantly regulated by ADCYs in AML (Figure 5C). This evidence concerns the gene ADCY1 and acute myeloid leukemia.