Using Kaplan-Meier analysis, we found that increased mRNA expression of ADCY2 (P = 0.03994), ADCY3 (P = 0.01924), ADCY4 (P = 0.02211), and ADCY7 (P = 0.01772) were significantly associated with poor overall survival (OS) in AML patients (Figure 3A). Here, ADCY4 is linked to acute myeloid leukemia.