This revealed a shift in the TAM population in the Cx3cr1‐Rheb1Δ/Δ tumours, with a significant decrease in TAM‐MG (CD45+ P2RY12+ CD49d−), while significantly higher numbers of TAM‐BMDM (CD45+ P2RY12− CD49d+) were observed (Fig 4B). This evidence concerns the gene ITGA4 and neoplasm.