The predicted impact of this transcriptional deregulation is an increase in the stimulation of the adaptive immune system by innate immune cells and consequently an increase in effector and cytotoxic T cells within the tumour; an effect which was confirmed by tissue and flow cytometry analyses, which revealed an increase in CD4+ and CD8+ T cells, and no significant changes in FoxP3+ cells in the Cx3cr1‐Rheb1Δ/Δ TME as well as an increase in infiltration, proliferation and effector function of CD4+ and CD8+ T cells. This evidence concerns the gene CD4 and neoplasm.