To determine whether mTOR signalling was deregulated in TAM, we assessed the activity of the pathway in GBM mouse models that recapitulate the genetic signatures of human GBM: GL261 allograft model, Ntv‐a;PDGFB + Shp53 (Bowman et al, 2016), Pten−/−; p53−/− (Jacques et al, 2010), Pten−/−; p53−/−; Idh1R132H and PDGFB genetic model (Zhang et al, 2019). Here, PTEN is linked to glioblastoma.