When comparing the cellular fractions between the Cx3cr1‐Rheb1Δ/Δ and Rheb1fl/fl GL261 tumours, a significant increase in CD8 cytotoxic T lymphocytes (CTL) and CD4 helper T (Th) cells was detected, with no changes in regulatory T (Treg) cells (Fig EV3D). This evidence concerns the gene CD4 and neoplasm.