In the tumour edge regions, all models except Ntv‐aPDGFB + Shp53 showed significant difference in the fraction of Iba1+ cells co‐expressing p‐S6 as compared to non‐tumour tissue (between 31% (± 4 SEM) the GL261 model and 72% (± 14 SEM) in the Pten−/−; p53−/− model; Fig 1B). This evidence concerns the gene TP53 and neoplasm.