Therefore, these results suggest that bone marrow neutrophils are overproduced and primed for NETosis in a G‐CSF dependent manner, which is a critical feature of subchondral BML in the CIA model.Although most researchers focus on the lesions of the synovium, cartilage, and bone cortex, in fact, the subchondral BM also has an important role in RA. This evidence concerns the gene CSF3 and rheumatoid arthritis.