The results of this case‐control study showed that the frequency of the HLA‐A*03:01 (odds ratio (OR) = 2.88, P value (Pv) = .002), HLA‐A*29:01 (OR = 15.31, Pv < .001), HLA‐DRB1*04:02 (OR = 3.41, Pv < .001), and HLA‐DRB1*16:01 (OR = 8.16, Pv < .001) was significantly higher in BD patients compared with healthy controls, whereas the frequency of the HLA‐DRB1*01:01 (OR = 0.03, Pv < .001) was significantly lower in BD patients. The gene discussed is HLA-DRB1; the disease is Behcet disease.