WFS1 and Hodgkins lymphoma: Our data provide that the de novo p.E864K mutation is first identified and de novo p.A684V mutation is likely to be a mutational hot spot in WFS1. Furthermore, we show that, even if a de novo mutation for hereditary HL is uncommon event, Sanger sequencing of asymptomatic parents must be performed in a sporadic case with an apparent dominant pathogenic variant.