In addition, G6PC significantly participates in abnormal immune infiltration of ccRCC cells and microenvironment, showing significantly negative association with check‐point immune signatures, dendritic cells, Th1 cells, MHC class I, cytolytic activity, inflammation promotion, HLA, APC co‐inhibition and co‐stimulation activities (cor.< −0.7, Figure 8C). This evidence concerns the gene G6PC1 and nonpapillary renal cell carcinoma.