PTEN and neoplasm: We analysed five phosphorylated proteins in the PI3K pathway (Miller et al. 2011b), p-AKT(Thr308), p-AKT(Ser473), p-4EBP1, p-p70S6K, p-S6RP(Ser240/244), as well as PTEN in primary tumour tissue and in a number of tumour biopsies immediately taken before drug dosing and linked these results with PFS.