Taken together, these results suggest that KLF4 may regulate EMT at several different stages of CRC progression, including suppression of expression of transcription factors (TWIST and SNAI2), transcriptional co-activator (β-catenin), and regulation of cell polarity (E-cadherin, N-cadherin, and claudin-1). Here, SNAI2 is linked to colorectal carcinoma.