PALB2 and breast carcinoma: Of note, four ASTs were detected for the P/LP variants, all on PALB2 (c.3114–1 G > A [splice site SNV], p.N455fs, p.Y28fs and p.E218fs), and significantly frequently co-occurred with germline PALB2 mutant breast cancers (OR = 776.0; p < 0.01, Fisher exact test; Tables 4 and 5)13.