BRCA1 and breast cancer: All 37 BRCA1/2 WT cases with 38 P or LP variants (35 SNVs/indels and 3 CNVs) had strong family history (HBOC history level 1 or 2; see Methods and Supplementary Note 1), and data were available regarding primary tumor site (breast or ovary), age at primary tumor diagnosis, breast cancer laterality, and other cancer type (Table 3 and Fig. 2)13.