In addition to BMI, the lack of correlation between markers of inflammation (CRP), insulin resistance (insulin), and increased adipose tissue (leptin), provided further evidence that poorer outcomes associated with elevated BMI are not due to increased circulating levels of estrogens as a result of peripheral aromatization in fatty tissues and inadequate suppression of aromatase by standard dosing of AI therapy5. The gene discussed is INS; the disease is Insulin resistance.