Genetic deletion of PPARD in mice showed lupus-like autoimmunity including higher levels of autoantibodies (in particular, the antinuclear antibody, ANA, and the double-stranded DNA, dsDNA) and renal impairment (increased urinary protein excretion, IgG deposition in glomeruli, and perivascular inflammation) [8]. Here, PPARD is linked to Autoimmunity.