CCKAR and type 2 diabetes mellitus: OLETF rats are an animal model of type 2 or non-insulin-dependent diabetes mellitus (NIDDM) that is characterized by deficiency in CCK-A receptors, hyperphagia, increase in meal size, mild obesity at about 6 weeks of age, late-onset insulin resistance at around 12 weeks, NIDDM at around 30 weeks, and DN induced after 30 weeks [79].